Anti-SLC34A1 Polyclonal Antibody for WB, ELISA - Q06495

Core Product Specifications and Parameters

Biological Background: Sodium-dependent phosphate transport protein 2A Function and Localization

• Sodium-dependent phosphate transport protein 2A (NaPi-2a), also known as solute carrier family 34 member 1 (SLC34A1), is a multi-pass transmembrane protein that belongs to the SLC34 family.
• It actively transports phosphate into cells via Na+ cotransport in the renal brush border membrane (PubMed:12324554, PubMed:20335586, PubMed:26047794). The cotransport has a Na+:Pi stoichiometry of 3:1 and is electrogenic. Related references: PMID:12324554 | PMID:20335586 | PMID:26047794
• The protein is localized to the apical cell membrane.
• It is primarily expressed in kidney and lung tissues.
• SLC34A1 contains disulfide bonds and is glycosylated and phosphorylated, as indicated by its UniProt keywords.
• Alternative splicing of the SLC34A1 gene produces multiple isoforms.
• Mutations in SLC34A1 are associated with disease variants, including osteoporosis.

Experimental Guidance and Technical Tips

• The immunogen encompasses the C-terminal region (amino acids 562-639) of human SLC34A1; consider using this recombinant fragment as a blocking peptide or positive control in ELISA.
• For Western blot, an expected band around 69 kDa may be detected. Validate in kidney tissue lysates from human, mouse, or rat, as SLC34A1 is highly expressed in the renal brush border membrane.
• Given the antibody's cross-reactivity with mouse and rat, it may be suitable for studies in rodent models; however, perform species-specific positive controls to confirm detection.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and researchers with integrated access to IVD raw materials, technical services, and consulting. For phosphate transport and renal function research, this anti-SLC34A1 polyclonal antibody is one of many validated antibody options available for bulk procurement. In addition to monoclonal and polyclonal antibodies, we supply ancillary reagents and can assist with sourcing rare targets to accelerate your assay development from concept to clinic.