Anti-SLC30A6 (Zinc Transporter 6) Rabbit Polyclonal Antibody for WB and ELISA - Q6NXT4

Core Product Specifications and Parameters

Biological Background: SLC30A6 Function and Localization

• SLC30A6 itself likely lacks intrinsic zinc transporter activity but forms an obligate heterodimer with SLC30A5 (ZNT5) to function as a zinc:proton antiporter, mediating zinc influx into the lumen of secretory organelles. Related references: PMID:15994300 PMID:19366695 PMID:19759014

• This heterodimer regulates zinc homeostasis within the early secretory pathway, which is critical for the activation and folding of zinc-dependent enzymes such as alkaline phosphatases and phosphatidylinositol glycan anchor biosynthesis enzymes. Related references: PMID:15994300 PMID:19759014 PMID:35525268

• The protein localizes to the Golgi apparatus, specifically the trans-Golgi network membrane, and also to the apical cell membrane.

• SLC30A6 is highly expressed in brain regions including cerebellum, hippocampus, and temporal gyri, as well as in B-cells, colon, eye, and lung, with lower expression in many other tissues.

• The SLC30A6 gene undergoes alternative splicing, and the protein belongs to the cation diffusion facilitator (CDF) family of metal ion transporters, featuring multiple transmembrane helices.

• With a predicted molecular weight of ~51 kDa, it is identified in proteomics studies and classified as a reference proteome component.

Experimental Guidance and Technical Tips

• The immunogen (amino acids 252–461) covers a cytoplasmic region of SLC30A6; consider using this antibody for Western blot to detect full-length and possibly truncated isoforms.
• For ELISA, the antibody can be used to capture or detect recombinant SLC30A6; validate against relevant controls.
• Given high expression in brain and B-cells, use lysates from these tissues/cell lines for initial optimization.
• Cross-reactivity to mouse and rat SLC30A6 suggests utility in rodent models, but confirm sequence homology in the immunogen region.
• The predicted molecular weight is ~51 kDa; run appropriate molecular weight markers and account for possible post-translational modifications.

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