Anti-SLC2A9 Rabbit Polyclonal Antibody for WB and ELISA - Q9NRM0

Core Product Specifications and Parameters

Biological Background: SLC2A9 Function and Localization

• SLC2A9, also designated GLUT9 or URATv1, is a facilitative glucose transporter family member that primarily acts as a high-capacity urate transporter.
• Functional characterization demonstrates that SLC2A9 transports urate at rates 45–60 fold higher than glucose; it also exhibits residual low-affinity glucose and fructose transport, does not transport galactose, and mediates small adenine uptake. Related references: PMID:18327257, PMID:18701466, PMID:22647630, PMID:18842065, PMID:28083649
• The protein localizes predominantly to the cell membrane, with specific isoforms targeted to basolateral or apical membranes in polarized renal epithelial cells and placenta.
• Tissue expression is highest in kidney proximal tubules, liver, and placenta, with detection in lung, leukocytes, heart, skeletal muscle, and articular cartilage chondrocytes.
• Post-translational modifications include glycosylation and phosphorylation; alternative splicing generates multiple isoforms, and genetic variants are associated with hyperuricemia and gout.

Experimental Guidance and Technical Tips

• For Western blot (WB), consider using human kidney or liver lysates as positive controls, given the high expression in these tissues. Optimize antibody dilution and blocking conditions.
• The recombinant immunogen (synthetic peptide corresponding to amino acids 429-529) can be used as a positive control in ELISA assays.
• Cross-reactivity with mouse and rat should be validated in the relevant sample system, as target epitope conservation may vary.
• The predicted protein molecular weight is approximately 59 kDa, but glycosylation may cause a shift; use appropriate molecular weight markers.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your one-stop partner for IVD raw materials, providing ready-to-use antibodies, antigen pairs, and bulk reagents for metabolic and renal disease research. We supply SLC2A9-targeting reagents along with comprehensive technical support to accelerate assay development from concept to clinic.