Anti-SLC27A6 Polyclonal Antibody for IHC-P, ELISA - Q9Y2P4

Core Product Specifications and Parameters

Biological Background: SLC27A6 Function and Localization

• SLC27A6 (also known as FATP6, ACSVL2, FACVL2, VLCS-H1) encodes the long-chain fatty acid transport protein 6, a member of the solute carrier family 27 involved in fatty acid metabolism.
• It functions as a long-chain fatty acid transporter at the plasma membrane, facilitating the import of LCFA into cells (PubMed:12556534). Related references: PMID:12556534
• Additionally, SLC27A6 acts as an acyl-CoA ligase, catalyzing the ATP-dependent formation of fatty acyl-CoA from long-chain and very-long-chain fatty acids (By similarity).
• The protein plays a critical role in regulating exogenous LCFA substrates in tissues with high beta-oxidation, particularly in the heart (PubMed:12556534). Related references: PMID:12556534
• Subcellular localization includes the cell membrane and sarcolemma, consistent with its role in fatty acid uptake.
• Tissue expression is highest in the heart, specifically in cardiac myocytes, with moderate expression in placenta, testis, and adrenal glands, and low levels in kidney, bladder, and uterus.
• Key biological processes linked to SLC27A6 encompass fatty acid metabolism, lipid transport, and acyl-CoA ligase activity (UniProt KEYWORDS).

Experimental Guidance and Technical Tips

• The immunogen comprises a recombinant fusion protein spanning amino acids 506-600 of human SLC27A6. This region may be conserved across species, supporting the reported cross-reactivity with mouse; consider validating in the relevant sample system.
• For IHC-P, heart tissue sections are an excellent positive control due to high cardiac myocyte expression. Optimize antigen retrieval and detection conditions for robust staining.
• In ELISA applications, the polyclonal nature may provide broad epitope recognition, potentially enhancing sensitivity; however, appropriate negative controls should be included to confirm specificity.
• Since the antibody detects both human and mouse SLC27A6, it can be utilized in translational research using mouse models of cardiac or metabolic diseases.
• The expected band size for SLC27A6 is approximately 70 kDa based on UniProt data (70112 Da), consistent with the product’s reported protein weight; confirm molecular weight markers in your system.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio supports diagnostic manufacturers and research laboratories by providing a streamlined procurement pathway for IVD raw materials, including validated antibodies, antigen pairs, and ancillary reagents. This anti-SLC27A6 polyclonal antibody, targeting a long-chain fatty acid transporter critical in cardiovascular and metabolic research, exemplifies our commitment to supplying high-quality reagents for difficult targets. Our sourcing network ensures consistent availability of bulk quantities, optimized monoclonal and polyclonal antibody preparations, and customized support to accelerate your assay development from concept to clinic.