Anti-SLC26A11 Polyclonal Antibody for WB, ELISA - Q86WA9

Core Product Specifications and Parameters

Biological Background: SLC26A11 Function and Localization

• SLC26A11, also known as Solute carrier family 26 member 11, is a sodium-independent anion exchanger that mediates transport of bicarbonate, chloride, sulfate, and oxalate across cell membranes.
• In high endothelial venule endothelial cells (HEVEC), SLC26A11 functions as a sodium-independent sulfate anion transporter, cooperating with SLC26A2 to mediate DIDS-sensitive sulfate uptake.
  Related references: PMID:12626430
• In the kidney, SLC26A11 mediates chloride-bicarbonate exchange to facilitate V-ATPase-dependent acid secretion (by similarity).
• In the cerebellum, SLC26A11 may operate as a chloride channel, contributing to chloride homeostasis and neuronal activity (by similarity).
• Subcellularly, SLC26A11 localizes to the cell membrane, lysosome membrane, and both apical and basolateral membranes of polarized cells.
• SLC26A11 is widely expressed, with highest levels in the brain, kidney, HEVEC, and placenta, and lower levels in pancreas, skeletal muscle, liver, lung, and heart.
• Key functional features include anion exchange, ion transport, and multiple transmembrane domains, highlighting its role in epithelial transport and pH regulation.

Experimental Guidance and Technical Tips

• The immunogen is a synthetic peptide from amino acids 500–600, located in the C‑terminal region; this may allow detection of full‑length SLC26A11 and potential C‑terminal fragments.
• For western blotting, validate specificity in your sample system; the predicted molecular weight is approximately 65 kDa (human), though post‑translational modifications or sample conditions may alter migration.
• In ELISA assays, the antibody can be used as a capture or detection reagent; consider pairing with another anti‑SLC26A11 antibody for a sandwich format to improve sensitivity.
• Cross‑reactivity with mouse SLC26A11 is indicated, making this antibody a candidate for mouse tissue studies; nonetheless, always confirm species‑specific reactivity in your experimental setup.

CamelBio: Your One-Stop Sourcing Bridge

SLC26A11 is a key transporter in kidney physiology, neurological function, and systemic ion homeostasis—making it an emerging target for diagnostic and research applications. CamelBio supplies this Abclonal rabbit polyclonal antibody as part of a comprehensive IVD raw‑material portfolio that also includes validated antibody pairs, optimized monoclonal antibodies, bulk ancillary reagents, and rare‑target sourcing services. From initial R&D to clinical assay development, CamelBio helps diagnostic manufacturers and laboratories accelerate their projects with reliable, one‑stop access to critical raw materials.