Anti-SLC25A39 Polyclonal Antibody for WB, IF-P, ELISA - Q9BZJ4

Core Product Specifications and Parameters

Biological Background: SLC25A39 Function and Localization

• SLC25A39, also known as solute carrier family 25 member 39, is a mitochondrial transporter belonging to the SLC25 family. The gene produces variants via alternative splicing (Keywords: Alternative splicing).
• It functions as a glutathione transporter, mediating the import of cytosolic glutathione into the mitochondrial matrix to maintain redox homeostasis. (PubMed:34707288, PubMed:35513392, PubMed:37917749) Related references: PMID:34707288 PMID:35513392 PMID:37917749
• Mitochondrial glutathione is critical for the activity and stability of iron-sulfur (Fe-S) cluster-containing proteins and for normal erythropoiesis. (PubMed:34707288) Related references: PMID:34707288
• The protein localizes to the mitochondrial inner membrane (SUBCELLULAR LOCATION: Mitochondrion inner membrane).
• It harbors transmembrane helices, a 2Fe-2S cluster binding site, and metal-binding domains, suggesting roles in iron-sulfur cluster biogenesis and possibly heme biosynthesis (Keywords).
• Expressed widely across human tissues, with particularly high levels in testis and kidney (PubMed:11139402). Related references: PMID:11139402

Experimental Guidance and Technical Tips

• The immunogen used is a recombinant fusion protein covering amino acids 170–250 of human SLC25A39 (NP_001137252.1). This C-terminal region may be conserved across species (cross-reacts with human, mouse, rat).
• Suitable applications include Western blotting (WB), immunofluorescence on paraffin sections (IF-P), and ELISA. For WB, expect a band near 39 kDa (calculated molecular weight 39249 Da). Validate the antibody in your specific sample type.
• For IF, permeabilization steps may be required to access the mitochondrial inner membrane localization. Co-staining with a mitochondrial marker is recommended to confirm specificity.
• The antibody is polyclonal and may detect multiple isoforms due to alternative splicing. Use appropriate controls to assess specificity.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive IVD raw-material partner, connecting diagnostic developers, laboratories, and research institutes with high-quality reagents and expert support from concept to clinic. This anti-SLC25A39 rabbit polyclonal antibody is tailored for mitochondrial biology and glutathione metabolism studies. In addition to this product, CamelBio provides validated antibody pairs, monoclonal/polyclonal antibodies, bulk ancillary reagents, and custom sourcing for rare targets to streamline your assay development and manufacturing.