Anti-SLC25A16 Rabbit Polyclonal Antibody for WB and ELISA - P16260

Core Product Specifications and Parameters

Biological Background: SLC25A16 Function and Localization

• SLC25A16 encodes the mitochondrial coenzyme A transporter, a multi-pass transmembrane protein localized to the inner mitochondrial membrane.
• It regulates coenzyme A homeostasis by mediating transport across the mitochondrial membrane. Evidence suggests it may import cytosolic coenzyme A into the matrix (PubMed:11158296, PubMed:40925986) or export 3'-dephospho-CoA from the matrix to the cytosol (PubMed:36316571). Related references: PMID:11158296 PMID:36316571 PMID:40925986
• The protein is also known as Graves disease autoantigen (GDA), reflecting its involvement in autoimmune thyroid disease.
• Alternative names include Graves disease carrier protein (GDC), mitochondrial solute carrier protein homolog, and solute carrier family 25 member 16.
• As a member of the mitochondrial carrier family, it is essential for metabolite exchange across the inner membrane.
• The protein has a molecular weight of approximately 36 kDa (36224 Da) and is conserved across human, mouse, and rat.

Experimental Guidance and Technical Tips

• The immunogen was designed from an internal region (amino acids 200-300) of human SLC25A16, which may detect both endogenous and overexpressed protein in WB. Consider using mitochondrial-enriched lysates for optimal signal.
• Predicted molecular weight is ~36 kDa; verify band migration under your experimental conditions.
• For ELISA, this polyclonal antibody can be used; titration and optimization are recommended to determine the optimal working concentration.
• Cross-reactivity with mouse and rat is expected due to sequence similarity; validate in the relevant sample system if needed.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio supports diagnostic manufacturers and researchers with a comprehensive portfolio of IVD raw materials, including validated antibody pairs, optimized monoclonal/polyclonal antibodies, and bulk ancillary reagents. This anti-SLC25A16 polyclonal antibody, designed for mitochondrial transporter and autoimmune disease studies, is part of our extensive catalog. For rare targets or custom sourcing needs, our team can assist in securing the right raw materials to advance your projects from concept to clinic.