Anti-SLC25A14 Rabbit Polyclonal Antibody for WB, ELISA - O95258

Core Product Specifications and Parameters

Biological Background: SLC25A14 Function and Localization

• Brain mitochondrial carrier protein 1 (BMCP1), also known as UCP5, is encoded by the SLC25A14 gene.
• It functions as a mitochondrial transporter of inorganic anions (sulfate, sulfite, thiosulfate, phosphate) and, to a lesser extent, dicarboxylates, aspartate, glutamate, and tricarboxylates, and may modulate hydrogen sulfide levels by exporting its degradation products. Related references: PMID:31356773
• The protein maintains oxidative balance through uncoupling activities and ATP production by modifying mitochondrial membrane potential. Related references: PMID:20600837
• SLC25A14 can transport protons across lipid membranes and exhibits transmembrane chloride transport activity. Related references: PMID:22524567, PMID:26182433
• It is predominantly expressed in the brain, with some expression in testis and pituitary. Related references: PMID:10928996
• Subcellular localization is the mitochondrial inner membrane.
• Belongs to the mitochondrial carrier (TC 2.A.29) family, containing characteristic repeats and transmembrane helices.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 25-200 within the N-terminal region of human SLC25A14 (isoform from NP_001269124.1). Consider using Western blotting with whole-cell lysates from brain-derived cell lines or tissues to detect endogenous protein at predicted ~36 kDa.
• As a polyclonal antibody, it may recognize multiple splice variants or post-translationally modified forms; optimize blocking and washing conditions.
• For ELISA, the recombinant protein used as immunogen can serve as a positive control; validate specificity in the relevant sample matrix.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers comprehensive IVD raw-material sourcing, including this SLC25A14 antibody suitable for mitochondrial research and metabolic studies. We support diagnostic manufacturers and labs with validated antibody pairs, bulk reagents, and rare target sourcing to streamline assay development.