Anti-SLC25A13/Citrin Rabbit Monoclonal Antibody for WB, IHC-P, ELISA - Q9UJS0

Core Product Specifications and Parameters

Biological Background: SLC25A13/Citrin Function and Localization

• SLC25A13, also known as citrin or Aralar2, is an electrogenic aspartate/glutamate antiporter located in the mitochondrial inner membrane.
• It plays a key role in the malate-aspartate shuttle, mediating the efflux of aspartate and the coupled uptake of glutamate and a proton into mitochondria. Related references: PMID:11566871, PMID:38937634, PMID:38945283
• The transporter can also facilitate the uptake of L-cysteinesulfinate in exchange for L-glutamate and a proton, or aspartate without proton translocation. Related references: PMID:11566871
• It does not transport gamma-aminobutyric acid (GABA). Related references: PMID:38945283
• SLC25A13 is highly expressed in the liver, with lower levels in the kidney, pancreas, placenta, heart, and brain.
• The protein is involved in calcium binding and is associated with intrahepatic cholestasis (citrin deficiency) as a disease variant.
• Post-translational modifications include acetylation, methylation, and phosphorylation.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal region (aa 1–300) of human SLC25A13. For WB, consider using the predicted molecular weight of 74 kDa as a reference.
• For IHC-P, validate in tissues with high expression such as liver; antigen retrieval conditions may need optimization.
• Cross-reactivity with mouse and rat suggests conserved epitopes; verify performance in these species experimentally.
• Due to the mitochondrial localization, ensure appropriate lysis and sample preparation for WB or ELISA to expose the membrane protein.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research labs with streamlined access to high-quality IVD raw materials. For your mitochondrial transporter and metabolic disorder studies, we offer validated antibody pairs, optimized monoclonal/polyclonal antibodies, and bulk ancillary reagents. Our supply network also supports rare-target raw-material sourcing to accelerate your assay development from concept to clinic.