Anti-SLC22A7 Rabbit Polyclonal Antibody for WB, ELISA - Q9Y694

Core Product Specifications and Parameters

Biological Background: SLC22A7 Function and Localization

• SLC22A7, also known as OAT2 or NLT, is a transmembrane protein belonging to the solute carrier 22 (SLC22) family.
• It operates as a Na+-independent bidirectional facilitative transporter for cyclic nucleotides, particularly cGMP, and may regulate cGMP signaling pathways. Related references: PMID:18216183, PMID:26377792
• The transporter mediates the uptake and efflux of various endogenous substrates including nucleosides, nucleotides, creatinine, glutamate, and urate, contributing to renal and hepatic clearance. Related references: PMID:11327718, PMID:18216183, PMID:21446918, PMID:25904762, PMID:26377792, PMID:28945155
• SLC22A7 localizes to both the basolateral and apical membranes of renal proximal tubule cells and hepatocytes, with some cytoplasmic expression.
• It is predominantly expressed in the liver and kidney, with lower levels in the pancreas, intestine, spinal cord, lung, brain, and heart; in kidney, it is specifically found in proximal tubular cells. Related references: PMID:11327718, PMID:18216183, PMID:21446918, PMID:25904762
• Alternative splicing produces a non-functional isoform of SLC22A7.
• The protein undergoes glycosylation and has a predicted molecular weight of about 60 kDa.

Experimental Guidance and Technical Tips

• The immunogen covers amino acids 50–142, an extracellular/luminal domain, potentially suitable for targeting native SLC22A7 conformations.
• For Western blotting, a band around 60 kDa is expected; glycosylation or other modifications may result in minor molecular weight shifts.
• In ELISA applications, consider testing antibody performance in both direct and sandwich formats with recombinant or native protein sources.
• Cross-reactivity with mouse and rat SLC22A7 suggests utility across rodent models, but validation in the specific experimental system is recommended.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your strategic partner for IVD raw-material sourcing, connecting diagnostic developers and researchers with antibodies, antigens, and ancillary reagents from concept to commercialization. This anti-SLC22A7 polyclonal antibody supports studies in renal and hepatic drug transport, pharmacokinetics, and transporter biology. Beyond single reagents, CamelBio offers validated antibody pairs, bulk production, and tailored sourcing for rare targets, streamlining your assay development workflow.