Anti-SLC20A1 Polyclonal Antibody for WB, IF/ICC, ELISA - Q8WUM9

Core Product Specifications and Parameters

Biological Background: SLC20A1 Function and Localization

• SLC20A1 (Solute carrier family 20 member 1) encodes the sodium-dependent phosphate transporter 1, also known as PiT-1 and GLVR-1 (Gibbon ape leukemia virus receptor 1).
• Functions as a sodium-phosphate symporter that preferentially transports the monovalent form of phosphate with a stoichiometry of two Na+ per phosphate. Related references: PMID:11009570, PMID:16790504, PMID:17494632
• Plays a role in extracellular matrix and cartilage calcification as well as in vascular calcification. Related references: PMID:11009570
• Essential for cell proliferation, but this function is independent of its phosphate transporter activity. Related references: PMID:19726692
• May function as a retroviral receptor, conferring susceptibility to infection by Gibbon Ape Leukemia Virus, Simian sarcoma-associated virus, Feline leukemia virus subgroup B, and 10A1 murine leukemia virus.
• Localized at the cell membrane and predicted to contain multiple transmembrane helices.
• Ubiquitously expressed across tissues.
• Classified as a phosphoprotein and involved in host-virus interactions, membrane transport, and symport activities.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 257–356 of human SLC20A1, a region that may be intracellular. Consider this antibody for detecting endogenous SLC20A1 in WB and IF/ICC.
• Predicted molecular weight is ~74 kDa. Validate band specificity in your sample system, as post-translational modifications (e.g., phosphorylation) may alter migration.
• Cross-reactivity with mouse and rat SLC20A1 is reported; verify performance in these species for comparative studies.
• For ELISA, optimize coating and detection conditions using recombinant SLC20A1 protein or cell lysates as controls.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides integrated IVD raw material sourcing—from validated antibody pairs and optimized polyclonal/monoclonal antibodies to bulk ancillary reagents. This anti-SLC20A1 antibody supports research into phosphate transport, calcification, and viral entry mechanisms. For rare target or custom development needs, contact our technical team for tailored solutions.