Anti-SLC1A4 Polyclonal Antibody for WB, ELISA - P43007

Core Product Specifications and Parameters

Biological Background: SLC1A4 Function and Localization

• SLC1A4 encodes the neutral amino acid transporter A (ASCT1), also known as alanine/serine/cysteine/threonine transporter 1, a member of the solute carrier family 1.
• Functions as a sodium-coupled antiporter that exchanges neutral amino acids such as L- and D-serine, L-threonine, L-asparagine, and L-alanine across the plasma membrane. Related references: PMID:14502423, PMID:26041762, PMID:27272177
• Plays a critical role in D-serine homeostasis in astrocytes at excitatory synapses, mediating electrogenic D-serine influx coupled to L-serine efflux and supporting de novo D-serine synthesis in neurons.
• Displays a sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) > NO3(-) > I(-) > Cl(-). Related references: PMID:8910405
• Localizes to the cell membrane and melanosome membrane.
• Expressed in most tissues, with highest levels in brain, muscle, and pancreas.
• Post-translational modifications include acetylation, phosphorylation, and glycosylation; alternative splicing generates multiple isoforms.
• Genetic variants are associated with neurological disorders including epilepsy and intellectual disability.

Experimental Guidance and Technical Tips

• The immunogen spans amino acids 140–220, a conserved cytoplasmic region, supporting the demonstrated cross-reactivity with human, mouse, and rat.
• For Western blot, expect a band of approximately 56 kDa; consider using positive control lysates from brain or pancreas tissues.
• Validate antibody performance in your specific sample and application, as optimal working dilutions may vary.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers diagnostic manufacturers and research laboratories a streamlined, one-stop sourcing solution for IVD raw materials, from early concept to clinical application. This anti-SLC1A4 polyclonal antibody supports investigations into amino acid transport and neurological disorders. Explore our comprehensive portfolio of validated antibodies, optimized recombinant proteins, and bulk ancillary reagents to accelerate your assay development and research.