Anti-SHOX2 Polyclonal Antibody for WB, ELISA - O60902

Core Product Specifications and Parameters

Biological Background: SHOX2 Function and Localization

• SHOX2 (Short stature homeobox protein 2), also known as OG12X or SHOT, is a member of the paired-related homeobox family of transcription factors.
• It functions as a growth regulator and is implicated in specifying neural systems involved in processing somatosensory information, as well as in facial and body structure formation.
• The protein localizes to the nucleus, consistent with its role as a DNA-binding transcription factor.
• SHOX2 is widely expressed in human tissues, including heart, skeletal muscle, liver, lung, bone marrow fibroblast, pancreas, and placenta.
• The gene undergoes alternative splicing, generating multiple transcript variants, and the protein is subject to proteomics-scale identification studies.
• Keywords from UniProt highlight its involvement in developmental processes, homeobox domain, DNA binding, and nuclear localization.

Experimental Guidance and Technical Tips

• The immunogen used for this antibody is a recombinant fusion protein corresponding to amino acids 96–355 of human SHOX2 (NP_003021.3); this region may include the homeobox domain critical for DNA binding.
• The antibody is applicable to Western blot (WB) and ELISA; for WB, the expected molecular weight is approximately 35 kDa, but alternative splicing or post-translational modifications could lead to size variations; validate in the relevant sample system.
• Cross-reactivity with mouse and rat is indicated, making it suitable for comparative studies in rodent models; however, species-specific validation is recommended.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers IVD manufacturers, laboratories, and research institutes seamless access to a wide array of raw materials, including validated antibody pairs and optimized monoclonal/polyclonal antibodies for developmental biology and neuroscience targets. With expertise in bulk ancillary reagents and rare target sourcing, we help streamline your workflow from concept to clinic. If you require custom formulations or additional support for SHOX2-related projects, our team can connect you with tailored solutions to accelerate your diagnostic or research development.