Anti-SFSWAP Rabbit Polyclonal Antibody for WB and ELISA - Q12872

Core Product Specifications and Parameters

Biological Background: SFSWAP Function and Localization

• Splicing factor, suppressor of white-apricot homolog (also known as SFRS8 or SWAP) is an arginine/serine-rich (R/S) protein involved in mRNA processing.
• Functions as an alternative splicing regulator, modulating its own pre-mRNA processing as well as the splicing of target genes, including fibronectin and CD45.
• Acts as a splicing repressor for MAPT/Tau exon 10, influencing tau protein isoform expression.
• May interact with other R/S-containing splicing factors to exert its regulatory effects on splice site selection.
• Localizes to the nucleus, consistent with its role in transcription and splicing.
• Subject to post-translational modifications such as phosphorylation and acetylation, which may modulate its activity and interactions.
• Additional annotations include RNA binding, transcription regulation, and the presence of repeated domains, reflecting its multifaceted roles in gene expression.

Experimental Guidance and Technical Tips

• The immunogen corresponds to a region (aa 170-280) of human SFSWAP, which is part of the N-terminal domain; consider potential detection of multiple isoforms due to alternative splicing events annotated for this protein.
• For Western blot, validate antibody specificity using appropriate positive and negative control lysates; a band of approximately 105 kDa is expected.
• Due to the polyclonal nature, cross-reactivity with closely related splicing factors cannot be excluded; confirm detection in the relevant sample system.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers comprehensive IVD raw material supply solutions, providing researchers and diagnostic developers with validated antibody pairs, optimized monoclonal and polyclonal antibodies, and bulk ancillary reagents. For your alternative splicing research needs, CamelBio can source rare-target raw materials and support seamless procurement, ensuring a reliable supply chain from discovery to clinical application.