Anti-SERPINI1 Rabbit Polyclonal Antibody for WB, IHC-P, ELISA - Q99574

Core Product Specifications and Parameters

Biological Background: SERPINI1/Neuroserpin Function and Localization

• Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. Related references: PMID:11880376, PMID:19265707, PMID:19285087
• May be involved in synaptic plasticity and protection of neurons from tissue-type plasminogen activator-induced damage.
• Predominantly expressed in brain, particularly in cortex and hippocampus pyramidal neurons, and detected in cerebrospinal fluid. Related references: PMID:17040209, PMID:25326458, PMID:9070919
• Localized to secretory vesicles, perikaryon, and secreted.
• Belongs to the serpin family; classified as a serine protease inhibitor, glycoprotein, and proteoglycan.
• Associated with neurodegeneration and disease variants.

Experimental Guidance and Technical Tips

• The immunogen covers the serpin domain (aa 181–410), likely recognizing native and recombinant SERPINI1; validate in the relevant sample system.
• Recommended applications based on supplier validation include WB, IHC-P, and ELISA; consider optimizing dilutions for your specific tissue or cell lysates.
• Cross-reactivity with mouse and rat is indicated; suitable for rodent brain studies, but verify specificity using knockout controls if available.
• For IHC-P, note that neuroserpin is secreted and cytoplasmic; permeabilization may be necessary, and appropriate negative controls are advised.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers a comprehensive portfolio of IVD raw materials, including validated antibody pairs and bulk reagents. For studies on neuroserpin and neurodegeneration, we provide high-quality antibodies like this SERPINI1 rabbit pAb, ensuring reliable performance in WB, IHC-P, and ELISA. As your one-stop sourcing partner, we also support procurement of auxiliary reagents and rare target materials to streamline your diagnostic development pipeline.