Anti-SERPING1 Rabbit Polyclonal Antibody for WB, IF/ICC, ELISA - P05155

Core Product Specifications and Parameters

Biological Background: SERPING1 Function and Localization

• SERPING1 encodes plasma protease C1 inhibitor, a member of the serpin superfamily, also known as C1 esterase inhibitor, C1-inhibiting factor, or serpin G1.
• It acts as a serine protease inhibitor that primarily regulates the classical complement pathway by forming proteolytically inactive complexes with C1r and C1s proteases. Related references: PMID:10946292 PMID:11527969 PMID:3458172 PMID:6416294
• The protein also inhibits other proteases such as FXIIa, chymotrypsin, and kallikrein, thereby modulating blood coagulation, fibrinolysis, and kinin generation. Related references: PMID:8495195
• Subcellular localization: SERPING1 is secreted into the extracellular space.
• Post-translational modifications include glycosylation and disulfide bond formation, consistent with its secretory function.
• Alternative splicing has been reported, potentially generating multiple isoforms.
• Mutations in SERPING1 are associated with hereditary angioedema (HAE), underscoring its clinical relevance.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 201–500 of human SERPING1 (accession NP_001027466.1); verify sequence homology if using non-human samples.
• This polyclonal antibody is applicable for western blotting (WB), immunofluorescence/immunocytochemistry (IF/ICC), and ELISA. For WB, the predicted molecular weight is ~55 kDa; consider including positive controls and validating in the relevant sample system.
• Cross-reactivity is reported for human, mouse, and rat; for other species, experimental validation is recommended.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is your one-stop partner for IVD raw-material sourcing, covering every stage from concept to clinic. This SERPING1 antibody supports research in complement biology, coagulation, and kinin–kallikrein pathways, and CamelBio can further provide validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and rare target raw-material sourcing to meet your diagnostic development needs.