Anti-SERPINA6 Rabbit Polyclonal Antibody for WB, ELISA - P08185

Core Product Specifications and Parameters

Biological Background: SERPINA6 Function and Localization

• SERPINA6, also known as corticosteroid-binding globulin (CBG) or transcortin, is a member of the serpin superfamily of protease inhibitors.
• It functions as the major transport protein for glucocorticoids (e.g., cortisol) and progestins in the blood of nearly all vertebrates, regulating their bioavailability and metabolic clearance.
• The protein is secreted and primarily synthesized in the liver, circulating in plasma; it has also been detected in glucocorticoid-responsive cells.
• SERPINA6 is a glycoprotein with steroid-binding and lipid-binding properties, highlighting its role in hormone transport and potential interactions with lipid membranes.
• Keywords associated with SERPINA6 include direct protein sequencing, disease variant, and proteomics identification, indicating its clinical and analytical significance.
• The molecular weight of the mature protein is approximately 45 kDa (UniProt: 45141 Da), consistent with the product's observed protein weight.

Experimental Guidance and Technical Tips

• The immunogen, a recombinant fusion protein covering amino acids 136-405 of human SERPINA6, ensures recognition of the mature protein. For Western blotting, consider using a reducing or non-reducing condition based on the target's disulfide bond status.
• Given the antibody's reactivity with human samples, validate cross-reactivity in your specific experimental context, particularly if working with closely related serpin family members.
• For ELISA applications, optimize the coating antigen and antibody concentration; this antibody may be used as a capture or detection reagent in sandwich assays.
• Always include appropriate controls (e.g., positive and negative cell lysates or recombinant protein) to confirm specificity and minimize background.

CamelBio: Your One-Stop Sourcing Bridge

• CamelBio acts as your one-stop sourcing partner for IVD raw materials, offering a comprehensive portfolio of antibodies, including validated polyclonal antibodies against human SERPINA6 for corticosteroid transport research and diagnostic assay development.
• Beyond individual antibodies, we supply optimized antibody pairs, bulk ancillary reagents, and provide technical support to accelerate your assay design, from concept to clinical application.
• With a focus on rare and specialized targets, CamelBio ensures reliable access to high-quality raw materials, enabling seamless procurement for laboratories and diagnostic manufacturers.