Anti-SERINC1 Rabbit Polyclonal Antibody for WB, IHC-P, and ELISA - Q9NRX5

Core Product Specifications and Parameters

Biological Background: SERINC1 Function and Localization

• Serine incorporator 1 (SERINC1) is a multi-pass transmembrane protein encoded by the SERINC1 gene, also known as tumor differentially expressed protein 2 (TDE2) or TDE1L.
• It belongs to the SERINC family of proteins, which function as serine incorporators and facilitate the biosynthesis of phosphatidylserine and sphingolipids.
• SERINC1 specifically enhances the incorporation of serine into membrane lipids, playing a central role in lipid metabolism and phospholipid biosynthesis.
• The protein localizes predominantly to the endoplasmic reticulum membrane, consistent with its role in lipid synthesis and trafficking.
• Post-translational modifications include N-linked glycosylation, myristoylation, and phosphorylation, which may regulate its activity, localization, or stability.
• The transmembrane topology and ER localization suggest that SERINC1 acts directly at the site of phospholipid production to modulate membrane composition.
• Research on the SERINC family has implications for understanding tumor biology, as SERINC1 was originally identified as a differentially expressed gene in tumors.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the C-terminal region (amino acids 350–453) of human SERINC1, which may provide specificity for this target without cross-reacting with other SERINC family members; however, experimental validation in the relevant sample system is recommended.
• For Western blotting, the predicted molecular weight is approximately 50 kDa. Use appropriate positive and negative controls to confirm specificity in your lysates.
• In immunohistochemistry (paraffin), antigen retrieval methods (e.g., heat-induced epitope retrieval) may be required for optimal signal; titration of the primary antibody is advised to reduce background.
• For ELISA, the polyclonal nature of this antibody allows versatile use in both direct and capture formats, but pairing with a compatible detection system should be optimized per assay.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers diagnostic manufacturers and research laboratories streamlined access to high-quality IVD raw materials, including validated antibodies for lipid metabolism targets such as SERINC1. Our supply capabilities encompass optimized monoclonal and polyclonal antibodies, bulk ancillary reagents, and custom sourcing for rare or specialized assay components. From concept to clinic, CamelBio supports your development pipeline with reliable, scalable procurement solutions.