Anti-SEMA4C Polyclonal Antibody for WB, ELISA - Q9C0C4

Core Product Specifications and Parameters

Biological Background: SEMA4C Function and Localization

• SEMA4C (Semaphorin-4C) is a member of the semaphorin family, functioning as a cell surface receptor for PLXNB2, and plays a critical role in cell-cell signaling during neural development and axon guidance.
• Upon PLXNB2 binding, SEMA4C triggers downstream activation of RHOA and promotes phosphorylation of ERBB2 at Tyr-1248, linking it to pathways that regulate cell migration and differentiation.
• Beyond neurogenesis, SEMA4C likely participates in myogenic differentiation through activation of the stress-activated MAPK cascade, indicating a broader signaling role.
• The gene is also known by aliases including KIAA1739, SEMAI, SEMAF, SEMACL1, and M-SEMA-F, reflecting its identification across multiple studies.
• Subcellularly, SEMA4C localizes to the postsynaptic density membrane and is also found in cytoplasmic vesicles, including secretory and synaptic vesicles, suggesting involvement in synaptic function and vesicular trafficking.
• Structural features include an immunoglobulin domain, a transmembrane helix, disulfide bonds, and glycosylation sites; the protein is also classified as a phosphoprotein and a reference proteome member.

Experimental Guidance and Technical Tips

• The immunogen used is a recombinant fragment corresponding to the C-terminal region (amino acids 749–833), making this antibody suitable for detecting full-length SEMA4C and potentially truncated forms.
• This antibody is recommended for Western blotting (WB) and ELISA applications; users should consider titrating the antibody to optimize for their specific sample and experimental conditions.
• Given the reported cross-reactivity with mouse SEMA4C, the antibody can be applied in mouse model studies, but validation in the relevant tissue or cell system is advised.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio serves as a comprehensive one-stop partner for IVD raw-material sourcing, catering to diagnostic manufacturers, research labs, and clinical developers with a full range of antibodies, bulk reagents, and ancillary materials. This SEMA4C polyclonal antibody supports critical studies in neurobiology, cell signaling, and development, and CamelBio can seamlessly extend your supply chain—from lead candidate acquisition and validation to scalable manufacturing—helping you accelerate from concept to clinic.