Anti-SELENOP/Selenoprotein P Polyclonal Antibody for WB, IF/ICC, ELISA - P49908

Core Product Specifications and Parameters

Biological Background: SELENOP Function and Localization

• Selenoprotein P (SEPP1/SELENOP, also known as SeP or SELP) is a secreted glycoprotein and phosphoprotein that contains selenocysteine residues, classifying it as a member of the selenoprotein family.
• It is primarily produced in the liver and heart and secreted into the plasma; it is also found in the kidney, indicating a systemic distribution.
• The protein functions as an extracellular antioxidant, potentially through its selenium-dependent activity, and may play a critical role in selenium transport and delivery to tissues such as the brain and testis.
• Its secretion is mediated by an N-terminal signal peptide, and it undergoes post‑translational modifications including glycosylation and phosphorylation, which may influence its stability and function.
• The mature protein has a molecular weight of approximately 43 kDa, consistent with the expected size based on its sequence.

Experimental Guidance and Technical Tips

• For western blotting, expect a band near 43 kDa; note that glycosylation may cause slight size shifts. Optimize detection using liver or plasma lysates where SELENOP is abundant.
• In immunofluorescence/immunocytochemistry, since SELENOP is secreted, consider using permeabilization and focusing on intracellular compartments such as the endoplasmic reticulum or Golgi for localization studies.
• For ELISA, this antibody may be suitable for detecting soluble SELENOP in serum or plasma; appropriate controls and standard curves should be included.
• The reported cross‑reactivity with mouse and rat makes it possible to use this antibody in commonly applied rodent models; however, validation in the user’s sample system is advisable.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research laboratories with a comprehensive supply chain for IVD raw materials, including validated antibodies, antigen pairs, and ancillary reagents. This anti‑SELENOP polyclonal antibody fits into studies on selenium metabolism and antioxidant defense, supporting assay development and biomarker research. Beyond individual products, we offer technical consulting, custom development, and bulk procurement to serve as your dedicated partner from concept to clinic.