Anti-SELENOM Rabbit Polyclonal Antibody for WB and ELISA - Q8WWX9

Core Product Specifications and Parameters

Biological Background: SELENOM Function and Localization

• SELENOM (Selenoprotein M) is a member of the selenoprotein family, characterized by the presence of the rare amino acid selenocysteine in its protein sequence.
• It is encoded by the SELENOM gene (also known as SELM or SEPM) in humans, producing a protein with a predicted molecular weight of approximately 16 kDa.
• SELENOM may function as a thiol-disulfide oxidoreductase, potentially participating in disulfide bond formation as part of protein folding and quality control.
• The protein localizes to the cytoplasm, particularly perinuclear region, as well as the endoplasmic reticulum and Golgi apparatus.
• SELENOM contains an N-terminal signal sequence that directs its expression and trafficking within the secretory pathway compartments.
• It is widely expressed across human tissues, indicating a potential fundamental role in cellular redox homeostasis and protein processing.

Experimental Guidance and Technical Tips

• The immunogen comprises a recombinant fusion protein spanning amino acids 50-130 of human SELENOM, which excludes the N-terminal signal peptide, potentially enhancing specificity for mature protein detection.
• For Western blotting, use standard denaturing/reducing conditions; the theoretical monomeric weight is ~16 kDa; validate band size using molecular weight markers and relevant controls (human or mouse cell/tissue lysates).
• When performing ELISA, titrate the antibody appropriately; for sandwich assays, pair with a well-characterized capture antibody recognizing a distinct epitope.
• Cross-reactivity with mouse SELENOM enables translation to murine model studies; verify signal in relevant mouse tissues expressing SELENOM.
• As a polyclonal antibody, lot-to-lot consistency may vary; consider performing batch-specific validation for critical applications.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, technical services, and consulting—covering every stage from concept to clinic. As your sourcing partner, we offer validated antibody pairs, optimized monoclonal/polyclonal antibodies like the anti-SELENOM reagent, bulk ancillary reagents, and rare target raw-material sourcing to accelerate your redox biology and protein folding research. Let CamelBio streamline your procurement with quality and reliability.