Anti-SEL1L Rabbit Monoclonal Antibody for WB, IHC-P, ELISA - Q9UBV2

Core Product Specifications and Parameters

Biological Background: SEL1L Function and Localization

• SEL1L (Suppressor of lin-12-like protein 1) is a single-pass type I transmembrane protein of the endoplasmic reticulum.
• Plays a key role in ER-associated degradation (ERAD) by enhancing SYVN1 stability and facilitating ubiquitin-dependent degradation of misfolded proteins. Related references: PMID:16186509 PMID:29997207 PMID:37943610
• Involved in lipoprotein lipase (LPL) maturation and secretion.
• Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells; highly expressed in pancreas.
• May play a role in Notch signaling.
• Post-translationally modified as a glycoprotein and phosphoprotein; contains disulfide bonds.

Experimental Guidance and Technical Tips

• The immunogen is a synthetic peptide spanning amino acids 251–350 of human SEL1L; consider this for high epitope specificity.
• For Western blot, the predicted molecular weight is approximately 89 kDa; optimize gel percentage and transfer conditions accordingly.
• In IHC-P, pancreatic tissue is recommended due to high SEL1L expression; validate in the relevant sample system.
• ELISA applications may require titration under standard conditions; include appropriate controls.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides a one-stop sourcing bridge for IVD raw materials, supporting researchers and manufacturers in ERAD, Notch signaling, and pancreatic studies. We supply validated antibody pairs, optimized monoclonal antibodies, and bulk ancillary reagents to streamline your assay development. With a focus on rare-target raw-material sourcing, CamelBio helps you accelerate from concept to clinic.