Anti-SEC62 Rabbit Monoclonal Antibody for WB, IF/ICC, IHC-P, ELISA - Q99442

Core Product Specifications and Parameters

Biological Background: SEC62 Function and Localization

• SEC62, also known as translocation protein 1 (TP-1, hTP-1), is a protein encoded by the SEC62 (TLOC1) gene in humans.
• Mediates post-translational transport of precursor polypeptides across the endoplasmic reticulum (ER) membrane.
• Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides.
• Properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen.
• Localizes to the endoplasmic reticulum membrane as a multi-pass transmembrane protein.
• Annotated as a phosphoprotein and involved in protein transport and translocation processes.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 214-314 of human SEC62; consider verifying sequence homology for your target species.
• For WB, the expected protein weight is ~46kDa; validate using appropriate molecular weight markers and controls.
• For IF/ICC or IHC-P, optimize fixation and permeabilization conditions to detect ER membrane-associated targets.
• Cross-reactivity with human, mouse, and rat is reported; confirm suitability for your experimental system.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio is a dedicated IVD raw-material partner supporting diagnostic manufacturers and research labs from concept to clinic. For SEC62-related ER protein transport studies, we offer validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and rare target sourcing—ensuring you have reliable materials for every workflow stage.