Anti-SCO1 Polyclonal Antibody for WB, IHC-P, ELISA - O75880

Core Product Specifications and Parameters

Biological Background: SCO1 Function and Localization

• SCO1 is a copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2) by delivering copper to the Cu(A) site, in cooperation with SCO2. Related references: PMID:15229189 PMID:15659396 PMID:16735468
• SCO1 also plays a role in regulating copper homeostasis by controlling the abundance and cell membrane localization of copper transporter CTR1 (By similarity).
• The protein is localized to the mitochondrial inner membrane.
• It is predominantly expressed in tissues with high oxidative phosphorylation, such as muscle, heart, and brain.
• Mutations in SCO1 are associated with primary mitochondrial disease (MC4DN4); the protein contains a disulfide bond, a transmembrane helix, and a copper-binding domain.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal region (aa 1-160) of human SCO1; consider this when designing detection strategies.
• For WB, validate the antibody in your specific sample system; the predicted molecular weight is approximately 34 kDa.
• For IHC-P, optimization of antigen retrieval conditions may be necessary.
• In ELISA, use appropriate recombinant SCO1 protein or peptide as a capture molecule or standard.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides a comprehensive portfolio of IVD raw materials, including this anti-SCO1 polyclonal antibody for mitochondrial disease research and diagnostic development. We support assay manufacturing with validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and rare-target sourcing. Let CamelBio streamline your transition from concept to clinic.