Anti-SCML1 Polyclonal Antibody for WB, ELISA - Q9UN30

Core Product Specifications and Parameters

Biological Background: SCML1 Function and Localization

• Sex comb on midleg-like protein 1 (SCML1) is a putative Polycomb group (PcG) protein that acts as part of multiprotein complexes to maintain the transcriptionally repressive state of homeotic genes throughout development.
• PcG complexes, including those containing SCML1, are essential for epigenetic silencing and cellular memory, ensuring stable gene expression patterns during differentiation.
• Functional characterization suggests SCML1 may play a role in spermatogenesis during sexual maturation (by similarity).
• The protein is ubiquitously expressed in both fetal and adult human tissues, indicating broad regulatory functions.
• SCML1 localizes exclusively to the nucleus, consistent with its role in chromatin-based gene regulation.
• Multiple isoforms are produced by alternative splicing, which may contribute to functional diversity and tissue-specific regulation.
• Post-translational modifications include phosphorylation, and the protein is classified as a phosphoprotein according to UniProt keywords.
• UniProt keywords also highlight its roles as a repressor, transcription regulator, and its involvement in reference proteome and proteomics identification.

Experimental Guidance and Technical Tips

• The immunogen covers amino acids 50–200 of human SCML1, a region that may be conserved across isoforms; validate specificity in your model system.
• For western blot (WB), the predicted molecular weight is approximately 37 kDa; consider using a reducing SDS-PAGE and appropriate loading controls.
• This antibody cross-reacts with rat SCML1, making it suitable for comparative studies; verify reactivity in relevant tissue lysates.
• For ELISA, optimize coating antigen and antibody dilution based on your specific assay format.
• Note that functional data are largely inferred by similarity; experimental validation of target knockdown or overexpression is advised for functional assays.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, laboratories, and research institutes with a comprehensive range of IVD raw materials, including validated antibody pairs, optimized polyclonal antibodies, and bulk ancillary reagents. This anti-SCML1 antibody supports epigenetic and developmental research, particularly in spermatogenesis and gene silencing studies. As a one-stop sourcing partner, CamelBio also facilitates rare-target raw material procurement and technical consulting to accelerate your transition from concept to clinic.