Anti-SCGB3A2 Polyclonal Antibody for WB, IF/ICC, ELISA - Q96PL1

Core Product Specifications and Parameters

Biological Background: SCGB3A2 Function and Localization

• SCGB3A2, also known as pneumo secretory protein 1 (PnSP-1) or uteroglobin-related protein 1 (UGRP1), is a member of the secretoglobin family.
• Functions as a secreted cytokine-like protein and binds to the scavenger receptor MARCO (PubMed:12847263). Related references: PMID:12847263
• Binds to various pathogens, including the Gram-positive bacterium Listeria monocytogenes, the Gram-negative bacterium Pseudomonas aeruginosa, and yeast, suggesting a role in innate immunity (PubMed:12847263). Related references: PMID:12847263
• Strongly inhibits phospholipase A2 (PLA2G1B) activity, which may contribute to its anti-inflammatory effects (PubMed:24213919). Related references: PMID:24213919
• Exhibits anti-fibrotic activity in the lung and plays a role in fetal lung development and maturation, including promoting branching morphogenesis during early stages (PubMed:24213919). Related references: PMID:24213919
• Predicted to be secreted, consistent with its extracellular functions.
• Highly expressed in lung and trachea, specifically in the airway epithelium, submucosal gland serous-like cells, and likely in club cells of the bronchioles; not detected in other tissues (PubMed:12175512, PubMed:12406855, PubMed:12847263). Related references: PMID:12175512 PMID:12406855 PMID:12847263
• May inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in the pituitary (By similarity).

Experimental Guidance and Technical Tips

• The immunogen corresponds to the full-length mature protein (amino acids 1-93), which may detect the secreted form of SCGB3A2; verify specificity in your sample type.
• For Western blotting, the predicted molecular weight is approximately 10 kDa; consider using a 15% SDS-PAGE gel and low molecular weight markers for optimal resolution.
• Suitable for immunofluorescence/immunocytochemistry (IF/ICC) and ELISA; ensure proper controls and validate antibody concentration in the relevant cellular or tissue context.
• Cross-reactivity with mouse and rat indicates potential for translational studies; confirm performance in your species and application of interest.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and researchers with one-stop access to IVD raw materials, supporting projects in respiratory disease, immunology, and developmental biology. Our portfolio includes validated polyclonal antibodies like anti-SCGB3A2, along with recombinant proteins, antibody pairs, and bulk ancillary reagents to accelerate immunoassay development. For rare or customized targets, our global sourcing network and technical consultation help bridge the gap from concept to clinic.