Anti-SBDS Rabbit Monoclonal Antibody for WB, ELISA - Q9Y3A5

Core Product Specifications and Parameters

Biological Background: SBDS Function and Localization

• SBDS (Shwachman-Bodian-Diamond syndrome protein) is a ribosome maturation factor encoded by the SBDS gene (GeneID: 51119), with a molecular weight of ~29 kDa (calculated 28.8 kDa).
• It is essential for 60S ribosomal subunit maturation: together with the GTPase EFL1, SBDS triggers the release of the anti-association factor EIF6 from pre-60S particles, enabling 80S ribosome assembly and translation.
• SBDS localizes to multiple cellular compartments including the cytoplasm, nucleolus, nucleoplasm, and mitotic spindle, consistent with its roles in ribosome biogenesis and cell division.
• The protein is widely expressed across tissues, reflecting its fundamental function in protein synthesis.
• Post-translational modifications such as acetylation have been identified, suggesting regulatory mechanisms that may influence SBDS activity or stability.
• Mutations in SBDS cause Shwachman-Diamond syndrome, an inherited disorder characterized by bone marrow failure and exocrine pancreatic insufficiency (keyword: Disease variant).

Experimental Guidance and Technical Tips

• The immunogen corresponds to a central region (aa 151–250) of human SBDS, which is highly conserved across human, mouse, and rat, supporting the observed cross-reactivity.
• For Western blot, a band at approximately 29 kDa is expected; consider using whole-cell lysates from human, mouse, or rat cell lines.
• For ELISA applications, the antibody can be considered for use as a capture or detection reagent, paired with an appropriate SBDS antibody; validate optimal dilutions in your specific assay system.
• As a rabbit monoclonal antibody, it offers high specificity and lot-to-lot consistency, but performance should be validated in the relevant sample matrix.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio specializes in supplying high-quality IVD raw materials, including recombinant monoclonal antibodies like this anti-SBDS antibody, suitable for developing ribosome assembly and Shwachman-Diamond syndrome diagnostic assays. Our portfolio covers validated antibody pairs, bulk ancillary reagents, and rare target sourcing to streamline your kit development. Whether you need optimized monoclonals or tailored raw-material solutions, CamelBio is your partner from concept to clinic.