Anti-Sall4 Monoclonal Antibody for IHC-P and ELISA - Q9UJQ4

Core Product Specifications and Parameters

Biological Background: Sall4/SALL4 Function and Localization

• SALL4 encodes Sal-like protein 4, also known as zinc finger protein 797 (ZNF797), HSAL4, DRRS, or IVIC.
• Functions as a zinc finger transcription factor crucial for the maintenance and self-renewal of embryonic and hematopoietic stem cells.
• Exhibits DNA-binding activity through its zinc finger domains, regulating transcription of target genes.
• Localizes to both the cytoplasm and nucleus, as reported in UniProt.
• Expressed in testis tissue and constitutively expressed in acute myeloid leukemia (AML), highlighting its role in oncogenesis.
• Involved in developmental processes; mutations are associated with Duane-radial ray syndrome (DRRS) and IVIC syndrome.
• Subject to post-translational modifications including phosphorylation and ubiquitination (isopeptide bond formation and Ubl conjugation).

Experimental Guidance and Technical Tips

• For immunohistochemistry (IHC-P), consider using antigen retrieval methods (e.g., heat-induced epitope retrieval) and validate staining in known positive tissues such as human testis or acute myeloid leukemia specimens.
• In ELISA applications, the recombinant immunogen may serve as a positive control; ensure appropriate dilution optimization.
• The predicted molecular weight is approximately 112 kDa; verify the band size in relevant sample systems if incorporating western blot or other applications.
• Due to SALL4 localization in both nucleus and cytoplasm, expect potential dual staining patterns in IHC.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, laboratories, and research institutes with one-stop access to IVD raw materials, technical services, and consulting—covering every stage from concept to clinic. Our portfolio includes validated SALL4 antibodies suitable for stem cell research and leukemia diagnostics, along with optimized antibody pairs and ancillary reagents. For rare target or custom requirements, our sourcing team ensures seamless procurement from discovery to commercialization.