Anti-S100A7/Psoriasin Rabbit Polyclonal Antibody for IHC-P, ELISA - P31151

Core Product Specifications and Parameters

Biological Background: S100A7/Psoriasin Function and Localization

• S100A7, also known as psoriasin or S100 calcium-binding protein A7, is a member of the S100 family of calcium-binding proteins.
• This protein is characterized by two EF-hand calcium-binding domains and binds both calcium and zinc ions, indicating roles in signal transduction and metal homeostasis.
• S100A7 is predominantly localized in the cytoplasm, but can also be secreted to exert extracellular functions, as suggested by its presence in urine of bladder SCC patients.
• It is highly expressed in fetal ear, skin, and tongue, and is dramatically upregulated in psoriatic epidermis, implicating it in keratinocyte differentiation and inflammatory skin responses.
• Post-translational modifications include acetylation and the formation of disulfide bonds, which may regulate its stability and interaction with target proteins.
• Direct protein sequencing data and multiple 3D structures are available, supporting its role as a well-characterized biomarker and therapeutic target.

Experimental Guidance and Technical Tips

• For IHC-P, consider using antigen retrieval techniques optimized for small calcium-binding proteins and validate with appropriate tissue controls expressing S100A7.
• In ELISA applications, this polyclonal antibody may be used as a primary antibody in direct or indirect formats; pairing with a matched detection antibody could enhance sensitivity, but performance should be validated in the relevant sample system.
• Given the secreted nature of S100A7, this antibody may be suitable for detecting the protein in cell culture supernatants or biological fluids; however, users should verify performance in their specific matrix.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, technical services, and consulting. For calcium-binding proteins like S100A7, we offer validated antibody pairs, optimized monoclonal and polyclonal antibodies, bulk ancillary reagents, and rare target sourcing to support your psoriasis and inflammation biomarker assay development.