Anti-S100A7/Psoriasin Polyclonal Antibody for WB, IHC-P, ELISA - P31151

Core Product Specifications and Parameters

Biological Background: S100A7/Psoriasin Function and Localization

• Protein S100-A7 is a member of the S100 calcium-binding protein family, also known as Psoriasin.
• It contains calcium-binding EF-hand motifs and can bind zinc, suggesting roles in metal ion homeostasis or signaling.
• S100-A7 is localized in the cytoplasm and can be secreted, indicating both intracellular and extracellular functions.
• It is highly up-regulated in psoriatic epidermis and found in the urine of bladder squamous cell carcinoma patients, making it a potential biomarker.
• Post-translational modifications include acetylation and disulfide bond formation, which may regulate its function.
• The protein has a molecular weight of approximately 11.5 kDa, consistent with its detection at ~11 kDa by Western blot.
• S100A7 is encoded by the S100A7 gene, with an alias PSOR1, linked to psoriasis susceptibility.

Experimental Guidance and Technical Tips

• The immunogen is a recombinant protein spanning amino acids 2-101, corresponding to nearly full-length human S100A7; thus, the antibody may recognize both cytoplasmic and secreted forms.
• For Western blot, the predicted molecular weight is ~11 kDa; consider using appropriate gel percentage and membrane pore size for low-molecular-weight proteins.
• In immunohistochemistry (IHC-P), antigen retrieval conditions may need optimization for detection in psoriatic skin or tumor tissues.
• For ELISA, the recombinant immunogen can serve as a positive control when validating the assay.
• Cross-reactivity is reported for human; validation in other species is not provided, so species-specific testing is recommended.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research labs comprehensive access to validated IVD raw materials like this anti-S100A7/Psoriasin polyclonal antibody. With expertise in inflammatory and cancer biomarker targets, we supply optimized antibody pairs, bulk ancillary reagents, and rare target sourcing to support your assay development from concept to clinic. Contact us for customized solutions in dermatological and oncological diagnostics.