Anti-RIMS2 Rabbit Polyclonal Antibody for WB, ELISA - Q9UQ26

Core Product Specifications and Parameters

Biological Background: RIMS2 Function and Localization

• RIMS2 (Regulating synaptic membrane exocytosis protein 2) is also known as Rab-3-interacting molecule 2 (RIM 2), Rab-3-interacting protein 3, OBOE, CRSDS, and RAB3IP3.
• Functions as a Rab effector protein critically involved in exocytosis; may act as a scaffold protein and contributes to dendrite formation in melanocytes (PubMed:23999003). Related references: PMID:23999003
• Localizes primarily to the cell membrane and presynaptic membrane at synapses, consistent with its role in neurotransmitter release.
• Widely expressed, with notable expression levels in the brain (fetal and adult), retina, cerebellum, and pancreas.
• Classified as a phosphoprotein and contains zinc-finger domains, indicating regulation by phosphorylation and metal-binding properties.
• Associated with disease variants and implicated in neurological differentiation, highlighting its relevance in synaptic pathology and neurodevelopmental research.

Experimental Guidance and Technical Tips

• The antibody is raised against the N-terminal region (aa 1-350) of human RIMS2, which may detect multiple isoforms due to alternative splicing.
• For Western blot, a band at approximately 160 kDa is expected; consider high-molecular-weight transfer protocols and adequate blocking.
• Cross-reacts with rat, making it suitable for rodent models in neuroscience studies.
• For ELISA, validate coating conditions and secondary antibody compatibility in your assay system.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio supports diagnostic manufacturers and research institutions with one-stop sourcing of high-quality IVD raw materials, including antibodies for neurological and synaptic targets such as RIMS2. Our portfolio covers validated antibody pairs, antigen-grade recombinant proteins, and bulk ancillary reagents needed throughout diagnostic development. Leverage our supply expertise to accelerate your projects with reliable and fully characterized reagents.