Anti-RGS2 Polyclonal Antibody for WB, IHC-P, ELISA - P41220

Core Product Specifications and Parameters

Biological Background: RGS2 Function and Localization

• RGS2, also known as G0S8 (G0/G1 switch regulatory protein 8) and cell growth-inhibiting gene 31 protein, is a regulator of G protein signaling that accelerates GTPase activity of G protein alpha subunits, driving them to inactive GDP-bound state, thereby inhibiting signal transduction. Related references: PMID:11063746 PMID:19478087
• It negatively regulates the angiotensin-activated signaling pathway, contributing to blood pressure control and vascular smooth muscle constriction/relaxation. Related references: PMID:28784619
• RGS2 also inhibits mRNA translation by binding to EIF2B5 and blocking its activity. Related references: PMID:19736320
• Subcellularly, RGS2 localizes to the cell membrane, cytoplasm, nucleus, nucleolus, and mitochondrion.
• It is expressed in acute myelogenous leukemia (AML) and acute lymphoblastic leukemia (ALL), and is associated with cell cycle regulation.
• Post-translational modifications include alternative initiation, isopeptide bond formation, phosphorylation, and ubiquitylation.
• Keywords associated with RGS2 include signal transduction inhibitor, translation regulation, GTPase activation, and phosphoprotein.

Experimental Guidance and Technical Tips

• The immunogen covers the full-length human RGS2 (aa 1-211); ensure that the target protein is expressed in your sample system, as tissue-specific expression may vary.
• For Western blotting, a band at ~24 kDa is expected; use appropriate controls such as known RGS2-expressing cell lines.
• In immunohistochemistry (paraffin), antigen retrieval may be necessary; optimize staining conditions for your specific tissue type.
• As a polyclonal antibody, performance may vary between batches; consider conducting validation experiments for each new lot.
• This antibody has been tested in ELISA; it may be suitable for other immunoassays, but independent validation is recommended.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with streamlined access to validated IVD raw materials, including bulk monoclonal and polyclonal antibodies, antibody pairs, and ancillary reagents. For researchers investigating G protein signaling, cardiovascular function, or leukemia, this RGS2 antibody supports core applications and can be integrated into larger assay development projects. CamelBio’s sourcing expertise also extends to rare-target reagents and custom material procurement, helping bridge the gap from concept to clinical testing.