Anti-REEP1 Rabbit Polyclonal Antibody for WB and ELISA - Q9H902

Core Product Specifications and Parameters

Biological Background: REEP1 Function and Localization

• Receptor expression-enhancing protein 1 (REEP1) is a transmembrane protein, also known as spastic paraplegia 31 protein (SPG31), with a molecular weight of ~22 kDa.
• Required for endoplasmic reticulum (ER) network formation, shaping, and remodeling by linking ER tubules to the cytoskeleton.
• May enhance the cell surface expression of odorant receptors (PubMed:20200447). Related references: PMID:20200447
• May play a role in long-term axonal maintenance (PubMed:24478229). Related references: PMID:24478229
• Localizes to the endoplasmic reticulum, mitochondrial membrane, and other membrane compartments.
• Expressed in testis and circumvallate papillae; alternative splicing generates multiple isoforms.
• Associated with hereditary spastic paraplegia (SPG31), neurodegeneration, and neuropathy.
• Post-translational modifications include phosphorylation.

Experimental Guidance and Technical Tips

• The immunogen (aa 101–201) targets a central region of human REEP1, likely recognizing multiple isoforms and splice variants.
• For Western blot, the predicted band is ~22 kDa; verify expression in relevant samples such as testis or neuronal cell lines.
• Cross-reactivity with mouse and rat suggests conserved epitopes; validate the antibody in the appropriate species model.
• For ELISA, optimize coating antigen concentration and antibody titration to ensure linear detection range.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research laboratories with one-stop access to validated IVD raw materials, including polyclonal and monoclonal antibodies, bulk ancillary reagents, and rare target sourcing. This anti-REEP1 antibody supports investigations into ER network dynamics, neurodegeneration, and spastic paraplegia. Whether you require antibody pairs, optimized reagents, or custom procurement, CamelBio streamlines your supply chain from concept to clinic.