Anti-RBM46 Rabbit Polyclonal Antibody for WB and ELISA - Q8TBY0

Core Product Specifications and Parameters

Biological Background: RBM46 Function and Localization

• RBM46, also known as Cancer/testis antigen 68 (CT68), is an RNA-binding protein essential for both male and female fertility, playing a critical role in germ cell development by ensuring proper progression through meiosis prophase I (By similarity).
• It regulates the mitotic-to-meiotic transition in spermatogenesis by forming a complex with MEIOC and YTHDC2, which recognizes and down-regulates mitotic transcripts to enable successful meiotic entry (By similarity).
• RBM46 is required for normal synaptonemal complex formation during meiosis; it binds to meiotic cohesin subunit mRNAs containing GCCUAU/GUUCGA motifs in their 3'UTRs and positively regulates their translation (By similarity).
• The protein is localized to the cytoplasm, consistent with its role in post-transcriptional regulation.
• RBM46 is also required for spermatogonial differentiation in both developing and adult testis (By similarity).
• Keywords include alternative splicing, RNA-binding, and differentiation, highlighting its multifaceted role in reproductive biology.

Experimental Guidance and Technical Tips

• For Western blotting, a band around 60 kDa is expected; consider using appropriate protein markers and optimizing blocking and antibody incubation conditions.
• The immunogen corresponds to the N-terminal region (aa 1-140), so the antibody may recognize full-length RBM46 and potentially any isoforms containing this region.
• In ELISA applications, validate the antibody using the recombinant immunogen as a positive control and assess performance in the relevant sample matrix.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, technical services, and consulting—covering every stage from concept to clinic. This RBM46 antibody supports reproductive biology and germ cell development research, and our supply capabilities include validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and sourcing of rare target raw materials. As a reliable B2B partner, we help streamline your procurement and accelerate your assay development.