Anti-RASD1 Rabbit Polyclonal Antibody for WB, ELISA - Q9Y272

Core Product Specifications and Parameters

Biological Background: RASD1 Function and Localization

• RASD1 (dexamethasone-induced Ras-related protein 1), also known as activator of G protein signaling 1 (AGS1), is a member of the Ras superfamily of small GTPases and undergoes alternative splicing.
• Functions as a small GTPase and acts as a negative regulator of the APBB1/FE65-APP complex transcription activity by interacting with APBB1/FE65 (by similarity).
• Localizes to multiple cellular compartments including the cell membrane, cytoplasm, perinuclear region, and nucleus.
• Expressed in a broad range of tissues, notably heart, cardiovascular tissues, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, gastrointestinal, and reproductive tissues.
• Key post-translational modifications include prenylation, methylation, and S-nitrosylation; the protein contains a GTP-binding domain and is associated with the lipoprotein membrane via prenylation.
• Relevant UniProt keywords: Alternative splicing, Cell membrane, Cytoplasm, GTP-binding, Lipoprotein, Membrane, Methylation, Nucleotide-binding, Nucleus, Prenylation, Proteomics identification, Reference proteome, S-nitrosylation.

Experimental Guidance and Technical Tips

• The immunogen covers amino acids 132–281 (C-terminal region) of human RASD1; consider validating specificity using full-length versus truncated constructs.
• For WB, a band near 32 kDa is expected; verify in lysates from tissues with known RASD1 expression such as heart or brain.
• ELISA applications may require optimization of coating antigen and antibody titrations; cross-reactivity with human and mouse suggests suitability for comparative studies.
• As a polyclonal antibody, lot-to-lot consistency should be monitored; include positive and negative controls in each experiment.

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