Anti-RASAL1 Rabbit Polyclonal Antibody for WB and ELISA - O95294

Core Product Specifications and Parameters

Biological Background: RASAL1 Function and Localization

• RASAL1 (RasGAP-activating-like protein 1) is a member of the Ras GTPase-activating protein (GAP) family.
• RASAL1 acts as an inhibitory regulator of the Ras-cyclic AMP signaling pathway. Related references: PMID:9751798
• RASAL1 contributes to dendrite formation in melanocytes, highlighting a role in cellular differentiation. Related references: PMID:23999003
• The protein contains zinc-finger domains and exhibits calcium and metal-binding properties, which may regulate its activity.
• Alternative splicing generates multiple RASAL1 isoforms, potentially with distinct functions.
• RASAL1 is highly expressed in thyroid and adrenal medulla, with lower expression in brain, spinal cord, and trachea, and is also detected in melanocytes.

Experimental Guidance and Technical Tips

• For Western blot, use the predicted molecular weight of approximately 90 kDa as a reference for band identification.
• Validate antibody specificity in ELISA using recombinant RASAL1 protein or lysates from tissues with known high expression (e.g., thyroid).
• The immunogen region (amino acids 120–340) is conserved across human, mouse, and rat, supporting cross-reactivity.
• Polyclonal antibodies may exhibit lot-to-lot variability; include an appropriate loading control in WB experiments.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research labs with one-stop access to IVD raw materials, technical services, and consulting. This anti-RASAL1 polyclonal antibody supports research into Ras signaling and dendrite formation. Our platform sources validated antibodies, bulk ancillary reagents, and rare targets to streamline assay development.