Anti-RAMP3 Rabbit Polyclonal Antibody for WB, IF/ICC, ELISA - O60896

Core Product Specifications and Parameters

Biological Background: RAMP3 Function and Localization

• RAMP3 (Receptor activity-modifying protein 3) is an accessory protein that interacts with and modulates the function of G protein-coupled receptors including CALCRL, CALCR, and GPER1. Related references: PMID:23674134, PMID:9620797
• It is required for the transport of CALCRL and GPER1 receptors to the plasma membrane. Related references: PMID:23674134, PMID:9620797
• Plays a cardioprotective role by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Related references: PMID:23674134
• Together with CALCRL, forms a receptor complex for adrenomedullin (ADM) and intermedin (ADM2). Related references: PMID:32296767
• With CALCR, it acts as a receptor complex for amylin (IAPP). Related references: PMID:35324283
• Subcellularly localized to the cell membrane via a transmembrane helix.
• Highly expressed in lung, breast, immune system, and fetal tissues.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 1-118 of human RAMP3 (NP_005847.1), covering the extracellular domain. For WB, a band at ~17 kDa (observed) may be detected; validate with appropriate controls.
• For IF/ICC, consider permeabilization protocols due to membrane localization and verify staining in relevant cell lines.
• Cross-reactivity with mouse and rat suggests conserved epitopes; confirm performance in your target species sample system.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides a comprehensive sourcing platform for IVD raw materials, supplying validated RAMP3 antibodies and ancillary reagents to support cardiovascular and metabolic disease research. Our global network offers optimized monoclonal/polyclonal antibodies, bulk reagent supply, and rare target raw-material procurement, helping diagnostic manufacturers accelerate assay development from concept to clinical application.