Anti-RABGGTA Polyclonal Antibody for WB, IF/ICC, ELISA - Q92696

Core Product Specifications and Parameters

Biological Background: RABGGTA Function and Localization

• RABGGTA encodes the alpha subunit of Rab geranylgeranyl transferase (Rab GGTase), also known as geranylgeranyl transferase type-2 subunit alpha.
• It catalyzes the transfer of a geranylgeranyl group from geranylgeranyl diphosphate (GGPP) to both cysteine residues of Rab proteins with C-terminal motifs -XXCC, -XCXC, or -CCXX.
• Target Rab proteins include key regulators of vesicular trafficking such as RAB1A, RAB3A, RAB5A, and RAB7A.
• The protein is a member of the protein prenyltransferase family and functions as a transferase.
• Structural features include leucine-rich repeats (LRRs), which often mediate protein-protein interactions.
• Post-translational modifications of RABGGTA include phosphorylation, as indicated by its classification as a phosphoprotein.

Experimental Guidance and Technical Tips

• The immunogen corresponds to a C-terminal region (aa 240–360), so the antibody may recognize full-length RABGGTA and possibly truncated variants; validate specificity in your system.
• For Western blot, anticipate a band around 65 kDa under reducing conditions; consider using positive controls such as HeLa or HEK293 cell lysates.
• In immunofluorescence/ICC, RABGGTA is expected to localize in the cytoplasm and possibly the nucleus; co-staining with organelle markers may aid interpretation.
• For ELISA, titrate the antibody against the recombinant immunogen or endogenous target in cell lysates to determine optimal working concentrations.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers this high-quality anti-RABGGTA polyclonal antibody as part of our comprehensive portfolio of IVD raw materials supporting research into protein prenylation and vesicular trafficking. As your one-stop sourcing partner, we provide validated antibody pairs, optimized monoclonal and polyclonal antibodies, bulk ancillary reagents, and rare-target raw material sourcing to streamline your diagnostic development from concept to clinic.