Anti-RAB2A Polyclonal Antibody for WB, ELISA - P61019

Core Product Specifications and Parameters

Biological Background: Ras-related protein Rab-2A Function and Localization

• RAB2A is a member of the small GTPase Rab family, cycling between active GTP-bound and inactive GDP-bound states to regulate intracellular membrane trafficking.
• It promotes autophagosome-lysosome fusion by recruiting the HOPS endosomal tethering complex, a process involving autophagosomal RAB2A and lysosomal RAB39A. Related references: PMID:37821429
• RAB2A is required for protein transport from the endoplasmic reticulum to the Golgi complex and maintains the compacted morphology of the Golgi. Related references: PMID:26209634
• Together with the closely related RAB2B, RAB2A is redundantly required for efficient autophagic flux. Related references: PMID:28483915
• Subcellular localization includes the endoplasmic reticulum-Golgi intermediate compartment, melanosome, ER membrane, Golgi apparatus membrane, cytoplasmic vesicles, secretory vesicles, acrosome, and autophagosome membrane.
• Post-translational modifications include prenylation for membrane anchoring and acetylation, as indicated by UniProt keywords.
• The protein belongs to the small GTPase superfamily, possessing GTP-binding and hydrolase activities, and is involved in key transport and trafficking pathways.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 1-212, covering the full-length human RAB2A; it may recognize both native and denatured protein forms.
• For Western blotting, consider optimizing the antibody dilution based on your specific sample and detection system; a band near 24kDa is expected.
• In ELISA applications, validate coating conditions and detection system using a positive control (e.g., recombinant RAB2A protein).
• Verify antibody specificity in biologically relevant samples from human, mouse, or rat due to reported cross-reactivity.
• Because this is a polyclonal antibody, lot-to-lot consistency may vary; include positive and negative controls in each experiment.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, labs, and research institutes with one-stop access to IVD raw materials, technical services, and consulting—covering every stage from concept to clinic. This RAB2A antibody supports research in membrane trafficking and autophagy, and CamelBio can further supply validated antibody pairs, optimized monoclonal/polyclonal antibodies, bulk ancillary reagents, and rare target raw-material procurement to accelerate your development.