Anti-RAB26 Rabbit Polyclonal Antibody for WB, ELISA - Q9ULW5

Core Product Specifications and Parameters

Biological Background: RAB26 Function and Localization

• RAB26 is a member of the Rab family of small GTPases, which are key regulators of intracellular membrane trafficking, controlling vesicle formation, movement, tethering, and fusion.
• Like other Rab proteins, RAB26 cycles between an inactive GDP-bound state and an active GTP-bound state, allowing it to recruit downstream effectors to membranes.
• RAB26 specifically mediates the transport of alpha-2A and alpha-2B adrenergic receptors (ADRA2A and ADRA2B) from the Golgi apparatus to the plasma membrane. Related references: PMID:23105096
• It plays an essential role in the maturation of zymogenic granules and in pepsinogen secretion within the stomach. Related references: PMID:20038531
• In the parotid gland, RAB26 is involved in the secretion of amylase from acinar granules (by similarity).
• At the subcellular level, RAB26 localizes to Golgi apparatus membranes and secretory vesicle membranes.
• The protein is predominantly expressed in brain tissue, indicating specialized functions in neuronal secretion.

Experimental Guidance and Technical Tips

• The immunogen corresponds to the N-terminal region (amino acids 1–60) of human RAB26, a sequence conserved across human, mouse, and rat, supporting the reported cross-reactivity.
• In Western blot analysis under reducing conditions, a primary band near 28 kDa (predicted molecular weight) may be observed; additional bands could represent post-translationally modified forms or splice variants.
• For ELISA, consider pairing this antibody with an appropriate capture antibody or recombinant protein to establish a robust detection system; validate sensitivity and specificity in the relevant sample matrix.
• Given the predominant expression of RAB26 in brain, brain lysates or enriched membrane fractions may serve as suitable positive controls for WB.

CamelBio: Your One-Stop Sourcing Bridge

As a specialized provider of IVD raw materials, CamelBio offers reliable access to validated antibodies and complementary reagents for diagnostic and research applications. For scientists investigating RAB26-dependent vesicle trafficking and exocytosis, this polyclonal antibody can be integrated into your workflow alongside bulk ancillary reagents and custom protein expressions. Our one-stop model simplifies procurement, from monoclonal/polyclonal antibody development to rare target sourcing, supporting your project from concept to clinic.