Anti-RAB17 Rabbit Polyclonal Antibody for WB, ELISA - Q9H0T7

Core Product Specifications and Parameters

Biological Background: RAB17 Function and Localization

• RAB17, also known as Ras-related protein Rab-17, belongs to the Rab family of small GTPases that regulate intracellular membrane trafficking from vesicle formation to fusion.
• It is specifically involved in transcytosis, directing the movement of endocytosed material through epithelial cells and its exocytosis from the opposite plasma membrane, likely via apical recycling endosomes (By similarity).
• RAB17 is required for melanosome transport and release from melanocytes, and regulates dendrite and dendritic spine development (By similarity).
• May also play a role in cell migration. Related references: PMID:22328529
• Subcellularly, RAB17 localizes to recycling endosome membranes, melanosomes, and cell projections such as dendrites.
• It is expressed in melanocytes at the protein level.
• Key structural features include GTP-binding, magnesium and metal-binding sites, nucleotide-binding, and a prenylation site for membrane association.
• Post-translational modifications include phosphorylation, and the protein is subject to alternative splicing.

Experimental Guidance and Technical Tips

• Given the immunogen design (recombinant protein covering amino acids 1-212), the antibody may recognize the native RAB17 protein in various species.
• For Western blotting, consider validating in human, mouse, or rat cell lysates, noting a predicted molecular weight of approximately 23 kDa.
• For ELISA, the antibody can be used as a capture or detection reagent in sandwich assays after optimization.
• As a polyclonal antibody, it may detect multiple splice isoforms; confirm specificity in your experimental system.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research laboratories with comprehensive access to IVD raw materials, including validated antibodies like anti-RAB17. Our sourcing network covers rare targets such as RAB17, along with bulk ancillary reagents and optimized antibody pairs, supporting your assay development from concept to clinic. With a focus on intracellular trafficking and transcytosis, we help streamline procurement for epithelial biology and drug delivery studies.