Anti-RAB11A Rabbit Monoclonal Antibody for WB, IF/ICC, ELISA - P62491

Core Product Specifications and Parameters

Biological Background: Ras-related protein Rab-11A Function and Localization

• Ras-related protein Rab-11A (RAB11A), also known as YL8, is a small GTPase of the Rab family that cycles between inactive GDP-bound and active GTP-bound states to regulate intracellular membrane trafficking. Related references: PMID:15601896 PMID:15689490 PMID:17462998
• RAB11A regulates endocytic recycling by forming a functional Rab11/RAB11FIP3/dynein complex that moves peripheral sorting endosomes along microtubules to generate the endosomal recycling compartment (ERC). Related references: PMID:20026645
• Acts as a major regulator of membrane delivery during cytokinesis. Related references: PMID:15601896
• Together with MYO5B and RAB8A, participates in epithelial cell polarization. Related references: PMID:21282656
• Promotes preciliary vesicular trafficking to the mother centriole by forming a ciliary targeting complex, thereby regulating ciliogenesis initiation. Related references: PMID:25673879 PMID:31204173
• Localizes to the recycling endosome membrane, cleavage furrow, Golgi apparatus, trans-Golgi network, cytoplasmic vesicle membrane, and cell projection cilium.
• Post-translational modifications include acetylation, prenylation, and methylation; functions as a lipoprotein involved in protein transport.

Experimental Guidance and Technical Tips

• The immunogen corresponds to a synthetic peptide within amino acids 100-200 of human RAB11A; consider using standard Western blotting, immunofluorescence, or ELISA protocols with this monoclonal antibody.
• Validate the antibody in the relevant sample system—HeLa cells or other models expressing RAB11A are suitable for endocytic recycling and membrane trafficking studies.
• Cross-reactivity with mouse and rat allows for translational research across species; ensure appropriate secondary detection reagents for rabbit monoclonal antibodies.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers diagnostic manufacturers and research laboratories integrated access to a wide range of IVD raw materials, including this RAB11A rabbit monoclonal antibody for endocytic trafficking research. Our supply capabilities encompass validated antibody pairs, optimized monoclonal and polyclonal antibodies, bulk ancillary reagents, and sourcing for rare-target raw materials. With a full chain from concept to clinic, CamelBio supports your development needs efficiently.