Anti-QSOX2 Polyclonal Antibody for WB and ELISA - Q6ZRP7

Core Product Specifications and Parameters

Biological Background: QSOX2 Function and Localization

• Protein identity: QSOX2 (Quiescin Q6-like protein 1, also known as SOXN/QSCN6L1) is a sulfhydryl oxidase belonging to the quiescin-sulfhydryl oxidase family.
• Core enzymatic function: Catalyzes the oxidation of protein thiol groups to form disulfide bonds, with reduction of oxygen to hydrogen peroxide; utilizes FAD as a cofactor.
• Protein folding role: May contribute to disulfide bond formation in secreted proteins, facilitating proper oxidative folding in the secretory pathway.
• Apoptosis regulation: Plays a role in regulating the sensitization of neuroblastoma cells for interferon‑gamma‑induced apoptosis. Related references: PMID:14633699
• Reproductive function: Required for normal ovarian function (by similarity).
• Subcellular localization: Detected at the cell membrane, nuclear membrane, and in secreted fractions.
• Tissue expression: Highly expressed in pancreas, brain, placenta, kidney, heart, and fetal tissues; weakly expressed in lung, liver, and skeletal muscle.
• Post‑translational modifications & motifs: Glycoprotein, phosphoprotein, signal peptide, transmembrane helix, and disulfide bonds.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 370–650, which covers a region likely important for substrate interaction; performance in WB and ELISA has been observed, but optimal dilutions and conditions should be determined empirically.
• For WB, consider reducing versus non‑reducing electrophoresis conditions as QSOX2 contains internal disulfide bonds that may influence electrophoretic mobility.
• Validate the antibody in neuroblastoma cell lines (e.g., SH‑SY5Y) or pancreatic/brain lysates known to express QSOX2.
• For ELISA, pairing with a validated detection antibody may be required; consider testing direct vs. sandwich formats.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio supports IVD developers, research labs, and diagnostic manufacturers with efficient access to critical raw materials. For QSOX2-related projects—oxidative folding, apoptosis regulation, or ovarian function—we offer validated antibody pairs, optimized polyclonal and monoclonal antibodies, bulk ancillary reagents, and sourcing assistance for rare targets, helping you streamline procurement from concept to clinic.