Anti-Purinergic Receptor P2Y6 Rabbit Polyclonal Antibody for WB, ELISA - Q15077

Core Product Specifications and Parameters

Biological Background: P2Y purinoceptor 6 Function and Localization

• P2Y purinoceptor 6 (P2RY6) is a G protein-coupled receptor that preferentially binds uridine diphosphate (UDP) over UTP and ATP.
• Upon activation, it couples to G proteins to stimulate the phosphatidylinositol-calcium second messenger system, leading to intracellular calcium mobilization.
• The receptor is localized to the cell membrane, consistent with its role in extracellular nucleotide sensing.
• P2RY6 is a member of the P2Y receptor subfamily, which mediates diverse physiological responses to extracellular nucleotides.
• The protein contains structural features typical of GPCRs, including seven transmembrane helices and a conserved disulfide bond.
• It is classified as a glycoprotein, indicating post-translational glycosylation that may influence receptor trafficking and function.

Experimental Guidance and Technical Tips

• The immunogen corresponds to an intracellular domain (amino acids 200–300) of human P2RY6, making the antibody suitable for Western blotting under denaturing conditions.
• For ELISA, consider using recombinant P2RY6 protein or the immunizing peptide as coating antigen.
• Due to the GPCR nature of the target, expression levels may be low; membrane-enriched fractions are recommended for Western blot detection.
• Cross-reactivity with mouse suggests sequence conservation, enabling use in rodent models with appropriate validation.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers diagnostic manufacturers and researchers streamlined access to IVD raw materials, technical services, and project support from concept to clinic. Pair this P2RY6 antibody with our validated antibody pairs, optimized polyclonals, or bulk ancillary reagents for nucleotide signaling and GPCR-targeted assay development. For rare target sourcing or custom raw-material needs, our team ensures reliable supply continuity.