Anti-PTPRD Polyclonal Antibody for WB, ELISA - P23468

Core Product Specifications and Parameters

Biological Background: PTPRD Function and Localization

• Receptor-type tyrosine-protein phosphatase delta (PTPRD) is a transmembrane receptor protein tyrosine phosphatase involved in neuronal development.
• It bidirectionally induces pre- and post-synaptic differentiation of neurons by mediating trans-synaptic interactions with IL1RAP and IL1RAPL1.
• PTPRD also promotes pre-synaptic differentiation through interaction with SLITRK2.
• It localizes to the cell membrane as a single-pass type I membrane protein.
• As a member of the protein tyrosine phosphatase family, it functions as a hydrolase, removing phosphate groups from phosphotyrosine residues.
• The protein undergoes glycosylation and contains disulfide bonds, which are important for its stability and function.
• Alternative splicing produces multiple isoforms, potentially contributing to functional diversity.

Experimental Guidance and Technical Tips

• The immunogen corresponds to amino acids 1100–1265 of human PTPRD, a region within the intracellular domain; consider this epitope location when designing detection or co-localization experiments.
• For western blotting, note the high molecular weight (~215 kDa); use a low-percentage polyacrylamide gel and optimize transfer conditions for large proteins.
• This polyclonal antibody is reported to react with human, mouse, and rat samples; validate in the relevant species and tissue type before quantitative studies.
• When performing ELISA, consider pairing this antibody with a capture antibody or direct detection strategy depending on the assay format.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers diagnostic manufacturers and research labs a streamlined source for IVD raw materials, including validated antibody pairs, bulk monoclonal/polyclonal antibodies, and ancillary reagents for neuroscience and synaptic biology targets like PTPRD. Our one-stop supply capability supports your workflow from antibody screening to scale-up, with rare-target sourcing and reliable shipment handling to keep your projects on track.