Anti-PSME2 Rabbit Polyclonal Antibody for WB, ELISA - Q9UL46

Core Product Specifications and Parameters

Biological Background: PSME2 Function and Localization

• PSME2, also known as PA28β or REGβ, is the beta subunit of the 11S regulator complex (PA28) that binds to the 20S proteasome.
• It is implicated in immunoproteasome assembly and is required for efficient antigen processing by the proteasome.
• The PA28 activator complex alters the cleavage pattern of the proteasome, enhancing the generation of class I binding peptides for MHC class I presentation.
• PSME2 is subject to post‑translational modifications including acetylation and phosphorylation, as identified by direct protein sequencing and proteomics.
• The protein has been structurally characterized (3D structure available) and is part of the reference proteome.

Experimental Guidance and Technical Tips

• When using this polyclonal antibody for western blotting, consider including a knockout‑validated negative control to confirm specificity.
• For ELISA applications, optimize antigen coating concentrations and antibody dilution ratios in your assay system.
• Given its cross‑reactivity with mouse, it may be used for comparative studies between human and mouse PSME2 expression.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic developers and researchers with streamlined access to high‑quality IVD raw materials. Our portfolio includes validated antibody products like this anti‑PSME2 polyclonal antibody, as well as monoclonal antibody pairs and ancillary reagents for immunoproteasome and antigen presentation studies. We also support rare target material sourcing and bulk supply to accelerate your diagnostic or research workflows.