Anti-PSMC2 Rabbit Polyclonal Antibody for WB, ELISA - P35998

Core Product Specifications and Parameters

Biological Background: PSMC2 Function and Localization

• PSMC2, also known as 26S proteasome regulatory subunit 7, MSS1, or RPT1, is an essential component of the 19S regulatory particle of the 26S proteasome.
• The 26S proteasome is responsible for ATP-dependent degradation of ubiquitinated proteins, playing a critical role in maintaining protein homeostasis by removing misfolded, damaged, or unnecessary proteins.
• This proteolytic system is involved in numerous cellular processes, including cell cycle progression, apoptosis, and DNA damage repair.
• PSMC2 belongs to the heterohexameric ring of AAA-ATPase subunits that unfold ubiquitinated target proteins and translocate them into the 20S proteolytic core for degradation.
• According to UniProt records, PSMC2 is localized to the cytoplasm.
• Post-translational modifications reported for PSMC2 include acetylation, phosphorylation, and ubiquitin-like conjugation; the protein also features ATP-binding and nucleotide-binding motifs.

Experimental Guidance and Technical Tips

• The immunogen covers the N-terminal 1-160 amino acid region of human PSMC2, which may confer target specificity; verify in relevant sample systems.
• For Western blot, whole‑cell lysates from human, mouse, or rat samples can be tested; the expected molecular weight is approximately 49 kDa.
• ELISA assays can be considered for quantitative detection; optimal antibody dilution should be determined empirically.
• Due to the polyclonal nature, lot‑to‑lot consistency should be monitored when switching batches for long‑term studies.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio streamlines IVD raw‑material procurement by connecting diagnostic manufacturers and labs with validated antibodies, such as this anti-PSMC2 polyclonal antibody, along with bulk ancillary reagents and technical support. With expertise spanning the proteasome‑ubiquitin pathway and protein degradation research, we offer one‑stop access to optimized antibody pairs, rare‑target raw materials, and comprehensive sourcing services. Let us help you move from concept to clinic with reliable, high‑quality biological tools.