Anti-PSMA2 Polyclonal Antibody for WB, ELISA - P25787

Core Product Specifications and Parameters

Biological Background: PSMA2 Function and Localization

• PSMA2 (Proteasome subunit alpha type-2) encodes a core alpha subunit of the 20S proteasome, also known as macropain subunit C3, multicatalytic endopeptidase complex subunit C3, and proteasome component C3.
• As a component of the 20S core proteasome, it participates in the proteolytic degradation of most intracellular proteins, maintaining protein homeostasis by removing misfolded or damaged proteins and those no longer needed.
• The 20S proteasome associates with 19S regulatory particles to form the 26S proteasome, which degrades ubiquitinated proteins in an ATP-dependent manner; it also associates with PA200 or PA28 for ubiquitin-independent degradation in pathways such as spermatogenesis and MHC class I antigen presentation.
• PSMA2 is localized in both the cytoplasm and nucleus.
• Post-translational modifications include acetylation and phosphorylation, as identified by proteomics.

Experimental Guidance and Technical Tips

• The immunogen spans nearly the full-length PSMA2 protein (amino acids 1-234), suggesting the polyclonal antibody may recognize multiple epitopes across the native protein.
• For Western blotting, expect a band around 26kDa; validate in the relevant sample system (e.g., human or mouse cell lysates).
• For ELISA, consider using the recombinant protein or peptide as a coating antigen and titrate the antibody to establish optimal working conditions.
• Cross-reactivity with human and mouse is reported; verify reactivity in other species if needed.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers, laboratories, and research institutes with streamlined access to IVD raw materials and technical support, covering the full development pathway from concept to clinic. Whether you need validated antibody pairs, optimized monoclonal or polyclonal antibodies, bulk ancillary reagents, or assistance sourcing rare targets like proteasome subunits, CamelBio’s integrated supply network and expertise ensure reliable procurement for your proteasome and ubiquitin-proteasome system research. Contact us to explore how we can accelerate your next diagnostic project.