Anti-PRR12 Rabbit Polyclonal Antibody for WB, ELISA - Q9ULL5

Core Product Specifications and Parameters

Biological Background: PRR12 Function and Localization

• PRR12 (Proline-rich protein 12), also known as NOC or KIAA1205, is a protein encoded by the PRR12 gene in humans.
• It may regulate the loading of the cohesin complex onto chromatin, potentially acting in coordination with NIPBL and MAU2.
• Localization includes the nucleus and synaptic compartments such as the postsynaptic density and synaptosome, indicating a role in chromatin dynamics and neuronal function.
• Post-translational modifications include acetylation and phosphorylation, which may regulate its activity.
• Associated with disease variants linked to intellectual disability, highlighting its importance in neurodevelopment.
• Alternative splicing generates multiple transcript variants, potentially diversifying its functional roles.

Experimental Guidance and Technical Tips

• The immunogen is a recombinant fusion protein covering amino acids 1687-2036 of human PRR12, which is predicted to be specific to conserved regions across human, mouse, and rat.
• For western blot, the predicted molecular weight is ~211 kDa; consider using appropriate gel percentage and transfer conditions for high-molecular-weight proteins.
• Validate antibody performance in relevant sample types (e.g., nuclear extracts or synaptic fractions) based on the known subcellular localization.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio provides diagnostic manufacturers and research laboratories with integrated access to high-quality IVD raw materials, from validated antibody pairs to bulk ancillary reagents. This PRR12 polyclonal antibody supports research into cohesinopathies and neurodevelopmental disorders, and can be sourced alongside complementary raw materials for chromatin and neuroscience research. Contact us to discuss custom sourcing for rare targets or scale-up needs.