Anti-PROP1 Rabbit Polyclonal Antibody for WB and ELISA - O75360

Core Product Specifications and Parameters

Biological Background: PROP1 Function and Localization

• PROP1 is a homeobox transcription factor, also known as pituitary-specific homeodomain factor, essential for pituitary development.
• It is involved in the ontogenesis of pituitary cell lineages, including gonadotropes, somatotropes, lactotropes, and caudomedial thyrotropes.
• The protein localizes to the nucleus, consistent with its role as a DNA-binding transcription factor.
• Expression is highly specific to embryonic pituitary tissue.
• Mutations in PROP1 are associated with combined pituitary hormone deficiency (CPHD2) and dwarfism, as indicated by its disease variant keyword.
• The protein contains a homeobox domain, characteristic of its DNA-binding function.

Experimental Guidance and Technical Tips

• The immunogen is a synthetic peptide from the central region (amino acids 50-150) of human PROP1. For western blot, a band around 25 kDa is expected.
• Due to cross-reactivity with mouse, the antibody may be suitable for detecting PROP1 in mouse embryonic pituitary lysates or tissues.
• For ELISA applications, consider pairing with a validated capture antibody or using the peptide as a control antigen.

CamelBio: Your One-Stop Sourcing Bridge

CamelBio offers a comprehensive sourcing bridge for IVD raw materials, supporting pituitary hormone research with validated antibodies like the PROP1 rabbit polyclonal. Our portfolio includes optimized antibody pairs, bulk ancillary reagents, and rare target raw-material sourcing, ensuring streamlined procurement from concept to clinic.